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Health

Team of scientists discover new molecules to treat cancer

02/28/2012

This article was translated by an automatic translation system, and was therefore not reviewed by people.



 


Discovery may intervene in the treatment of brain tumors and skin
A Franco-Italian team of scientists has discovered a new family of molecules that can supposedly involved in the treatment of various cancers, especially skin and brain tumors, said on Monday the French National Centre for Scientific Research (CNRS in French acronym).

The experts identified from tests in laboratory, molecules that block the Hedgehog signaling pathway, a complex chain of biochemical reactions that are behind different types of cancer.

These disorders are particularly caused by mutations in Smoothened, a membranous receptor that allows the activation of the Hedgehog.

So far, according to note CNRS, several pharmaceutical companies have developed molecules that are capable of blocking these disorders, but new mutations in tumor cells in Smoothened are resistant to these molecules.

The team examined banks with a total of 500 000 molecules computerized and, after modifying the structure of one of them found a new family of compounds called MRT.

After examining them, especially the MRT 83, scientists discovered that the compounds could block the proliferation of cells suspected cause brain tumors, even with a larger capacity than the molecules known so far.

The results of this survey, developed by the CNRS and the University of Siena (Italy), will be published in the medical journal "Chemistry."



Source: R7 News

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