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New generation of drugs acting in the treatment of psoriasis

08/30/2010

This article was translated by an automatic translation system, and was therefore not reviewed by people.

 



Disease that affects about 100 million people worldwide, psoriasis still stigmatizes their patients and challenges the pharmaceutical industry in pursuit of a drug more effective for its control. The need for new therapies and issues involving the medications currently available in the market will be the theme of the 65th Brazilian Congress of Dermatology to be held between 4 and 7 September in Rio de Janeiro.

During the event, the U.S. expert Mark Lebwohl, a dermatologist at Mount Sinai Medical Center in New York, will discuss new treatments for psoriasis, addressing research that proves the efficiency of newly released drugs that bring more relief to the patient.
They are called biological drugs, as is the case of Ustekinumab and Briakinumab, whose role is to block cytokine-specific disease responsible for damage to the patient.

Special attention will be given to the effectiveness and safety profile of biological medicines, especially those known in medical circles as TNF blockers.
Although very expensive, these medications have a cost-benefit quite satisfactory for severe or extensive psoriasis.

"For a disease that mainly affects the skin, body, external and visible, the patient's self-esteem is badly damaged. These new drugs represent a very good news for patients, by having superior efficacy to standard therapies," he believes.

The doctor also explains that psoriasis is a hereditary disease that affects the immune system and manifests itself in the skin and joints prominently.
Recent data, which will be discussed in the lecture, suggest that psoriasis is also a systemic disease, which can affect the cardiovascular system.

Luna Azulay, president of the congress, it reinforces that normally comes along with associated diseases, such as increased cholesterol and triglycerides, obesity, hypertension, diabetes, alcoholism, depression, among others.
Stress can trigger or worsen the tables.

Luna Second, although no cure, psoriasis can be well controlled if patients are properly diagnosed and treated.
"Patients often become desperate and tend to accept any treatment, such as the so-called alternative or taken orally or injected with cortisone. It takes a lot of discretion, or otherwise, the problem is getting worse," explains.

Types of psoriasis

Plaque: most common type, with pink or red lesions covered with white scales.

Reversed: light red lesions that usually arise in areas of folds such as armpits and groin.

Drops: second most common type, with small lesions that resemble drops.

Palmoplantar: localized lesions on the palms or soles.

Erythrodermic: the most serious and least common, with inflammation and red spots in large areas of skin.

Nail: When the lesions of psoriasis attack the nail, which may cause them to stiffen and peeling of skin that lies underneath.

Psoriatic arthritis: a small percentage of patients with psoriasis may have inflammation in joints and cartilage, developing pain and difficulty in physical movement.

Pustular: acute form, with lesions that have the appearance of pus.

As manifested
In general, appear in the adult unit, with small red lesions on the skin, increasing, itch and become whitish.
Psoriasis starts in the extremities, areas of friction (knees, elbows, lower back, scalp and nails)

Treatment
It can be done with the use of oral and topical (in the form of ointment), in addition to phototherapy (light bath in special chambers)

Medicines
The new generation of drugs, biologics, also acts in the patient's immunity.
They are expensive and can only be obtained if the patient does not respond well to the other two trials of treatments with different therapies, according to consensus on psoriasis published by the Brazilian Society of Dermatology, as they have other immunological implications.

Definition
Psoriasis is an inflammatory skin disease, chronic non-contagious, cause still unknown and that affects about 2% of the population in general. Indiscriminately afflict men and women, being more frequent in Caucasians. This is a problem with the immune system and can be triggered depending on the environment or genetic background.
It is also a systemic disease (affects other organs).


Source: Uai News

Vanessa Jacinto - State of Minas

This article was translated by an automatic translation system, and was therefore not reviewed by people.

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