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06/05/2017
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According to a study by the Polytechnic University of Marche, sleeping little leverage risks neurological diseases
FOR THE GLOBAL 05/06/2017 14:32
A study from the Polytechnic University of Marche in Italy has found that one of the effects of sleep deprivation is for the brain to self-consume in a process called astrocytic phagocytosis. The study, published in late May in the Journal of Neuroscience, was performed on mice, comparing those who had their normal sleep respected with others who were deprived of healthy sleep for five nights in a row.
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The problem, however, lies in the consequence of this behavior, which is the over-activation of cells that are directly related to neurological diseases, such as Alzheimer's disease.
"We show for the first time that portions of synapses are literally eaten by astrocytes due to sleep deprivation," researcher Michele Bellesi told New Scientist magazine. According to him, the finding helps explain how sleeping improves the risks of developing Alzheimer's as well as other neurological problems.
Bellesi's team analyzed the glial cells responsible for brain storage and found that the activity of these cells is more active after a period of sleep deprivation. One type of these cells is called astrocyte and another type, microglia.
Astrocytes are neural cells that, in case of poor sleep, can break synapses. In the short term, the study concluded that this may be beneficial because it promotes cleansing in the brain as well as rebuilding circuits that can protect healthy brain connections. According to the study, rodent astrocytes who slept well were active in approximately 6% of synapses. For those who stayed awake, they were even more active (8%).
In this second case, although the astrocytes managed to go beyond the common cleaning, to consume synapses that supposedly were not supposed to, the main problem found by the scientists was that this behavior accelerated the performance of the microglia.
In addition, the mice that did not have their hours of sleep respected, also had greater activation of the microglia. This is harmful because it is related to neurological diseases. "We already knew that microglial activation is seen in patients with Alzheimer's and other neurodegenerative diseases," Bellesi added.
Read more: https://lobo.globo.com/society/health/private-of-sono-can-cause-fagocitose-of-cellulas-cerebrais-indicate-italian search -21436493#ixzz4j9OWZBnH
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Source: The Globe
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This article was translated by an automatic translation system, and was therefore not reviewed by people.